Toxigenicity of Clostridium histolyticum

Toxigenicity of Clostridium histolyticum.

Nishida, Shoki (Kanazawa University, Kanazawa, Japan), and Masaaki Imaizumi. Toxigenicity of Clostridium histolyticum. J. Bacteriol. 91:477-483. 1966.-From 234 soil samples, 21 strains of Clostridium histolyticum of different levels of alpha-toxigenicity were isolated by a new method specially designed for the isolation of this species. The alpha-toxigenicity of freshly isolated strains and of ...

Injectable collagenase clostridium histolyticum for Dupuytren's contracture.

BACKGROUND Dupuytren's disease limits hand function, diminishes the quality of life, and may ultimately disable the hand. Surgery followed by hand therapy is standard treatment, but it is associated with serious potential complications. Injection of collagenase clostridium histolyticum, an office-based, nonsurgical option, may reduce joint contractures caused by Dupuytren's disease. METHODS W...

Ccxx. Enzymic Adaptation in Clostridium Histolyticum

RECENTLY Kocholaty & Hoogerheide [1938] described an example of the adaptation of certain of the endo-enzymes of the strict anaerobe Cl. sporogenes: by varying thepH ofthe culture medium a considerable shift in the pH optimum of some of the dehydrogenases could be produced. It has now been found that under specified conditions the pH optimum of the proteinase secreted by this micro-organism can...

i83. THE PROTEINASES OF CLOSTRIDIUM HISTOLYTICUM

Gene duplication and multiplicity of collagenases in Clostridium histolyticum.

Clostridium histolyticum collagenase contains a number of different active components. Previously we have shown that colH encodes a 116-kDa collagenase (ColH) and a 98-kDa gelatinase. We purified a different 116-kDa collagenase (ColG) from the culture supernatant and sequenced its gene (colG). We also identified four other gelatinases (105, 82, 78, and 67 kDa) and determined their N-terminal am...